PneumoRecs VaxAdvisor
PCV21 contains eight new pneumococcal serotypes not included in PCV15, PCV20, or PPSV23. However, PCV21 doesn’t contain certain pneumococcal serotypes (e.g., serotype 4) included in other pneumococcal vaccines.
In certain adult populations in the Western United States with data (Alaska, Colorado, New Mexico, Navajo Nation, and Oregon), serotype 4 has caused high percentages (i.e., ≥30%) of invasive pneumococcal disease (IPD). We currently don’t know if this is seen in other parts of the Western United States that don’t routinely monitor IPD data.
Typically, individuals living within these geographic areas who develop serotype 4 IPD are adults aged <65 years with specific underlying conditions or risk factors such as alcoholism, chronic lung disease, cigarette smoking, homelessness, and injection drug use. Importantly, these individuals usually haven’t received a PCV containing serotype 4. In such populations, other recommended pneumococcal vaccines (e.g., PCV20 alone or both PCV15 and PPSV23) are expected to provide broader serotype coverage against locally circulating strains compared to PCV21 alone.
- Alcoholism
- Cerebrospinal fluid (CSF) leak
- Chronic heart1, liver, or lung2 disease
- Chronic renal failure
- Cigarette smoking
- Cochlear implant
- Congenital or acquired asplenia
- Congenital or acquired immumnodeficiency3
- Diabetes mellitus
- Generalized malignancy
- HIV infection
- Hodgkin disease
- latrogenic immunosuppression4
- Leukemia
- Lymphoma
- Multiple myeloma
- Nephrotic syndrome
- Sickle cell disease and other hemoglobinopathies
- Solid organ transplant
Footnotes:
1. Including congestive heart failure and cardiomyopathies, excluding hypertension
2. Including chronic obstructive pulmonary disease, emphysema, and asthma
3. Includes B- (humoral) or T-lymphocyte deficiency, complement deficiencies (particularly C1, C2, C3, and C4 deficiencies), and phagocytic disorders (excluding chronic granulomatous disease)
4. Diseases requiring treatment with immunosuppressive drugs, including long-term systemic corticosteroids and radiation therapy
Please Note: Recommendations will be based on the leading risk factor selected: Cochlear implants and CSF leaks
Please Note: Recommendations will be based on the leading risk factor selected: Immunocompromising conditions
- Alcoholism
- Chronic heart1, liver, or lung2 disease
- Cigarette smoking
- Diabetes mellitus
Footnotes:
1. Including congestive heart failure and cardiomyopathies, excluding hypertension
2. Including chronic obstructive pulmonary disease, emphysema, and asthma
- Cerebrospinal fluid (CSF) leak
- Cochlear implant
- Chronic renal failure
- Congenital or acquired asplenia
- Congenital or acquired immumnodeficiency3
- Generalized malignancy
- HIV infection
- Hodgkin disease
- latrogenic immunosuppression4
- Leukemia
- Lymphoma
- Multiple myeloma
- Nephrotic syndrome
- Sickle cell disease and other hemoglobinopathies
- Solid organ transplant
Footnotes:
3. Includes B- (humoral) or T-lymphocyte deficiency, complement deficiencies (particularly C1, C2, C3, and C4 deficiencies), and phagocytic disorders (excluding chronic granulomatous disease)
4. Diseases requiring treatment with immunosuppressive drugs, including long-term systemic corticosteroids and radiation therapy
19 through 64 years
Risk Factors:
Pneumococcal ACIP Vaccine Recommendations
Recommended Immunization Schedule for Adults
Recommended Immunization Schedule for Children and Adolescents
Pneumococcal Vaccination: Information for Healthcare Professionals
Pneumococcal Vaccine Timing for Adults (PDF)
Pneumococcal Vaccine Shared Clinical Decision-Making for Adults (PDF)