NIOSHTIC-2 Publications Search

Search Results

New Search

Advanced Search Search Help About NIOSHTIC-2 Feedback

Terms: mead 41 - 41 of 262 Bibliographic entries

Save All Save Page View Saved Download

Select check boxes to automatically save entries, or use 'save all' or 'save page' links above.

Back to Results

Association of MHC region SNPs with irritant susceptibility in healthcare workers.

Authors

Yucesoy-B; Talzhanov-Y; Barmada-MM; Johnson-VJ; Kashon-ML; Baron-E; Wilson-NW; Frye-B; Wang-W; Fluharty-K; Gharib-R; Meade-J; Germolec-D; Luster-MI; Nedorost-S

Source

J Immunotoxicol 2016 Sep; 13(5):738-744

Link

http://dx.doi.org/10.3109/1547691X.2016.1173135

NIOSHTIC No.

20048111

Abstract

Irritant contact dermatitis is the most common work-related skin disease, especially affecting workers in "wet-work" occupations. This study was conducted to investigate the association between single nucleotide polymorphisms (SNPs) within the major histocompatibility complex (MHC) and skin irritant response in a group of healthcare workers. 585 volunteer healthcare workers were genotyped for MHC SNPs and patch tested with three different irritants: sodium lauryl sulfate (SLS), sodium hydroxide (NaOH) and benzalkonium chloride (BKC). Genotyping was performed using Illumina Goldengate MHC panels. A number of SNPs within the MHC Class I (OR2B3, TRIM31, TRIM10, TRIM40 and IER3), Class II (HLA-DPA1, HLA-DPB1) and Class III (C2) genes were associated (p<0.001) with skin response to tested irritants in different genetic models. Linkage disequilibrium patterns and functional annotations identified two SNPs in the TRIM40 (rs1573298) and HLA-DPB1 (rs9277554) genes, with a potential impact on gene regulation. In addition, SNPs in PSMB9 (rs10046277 and ITPR3 (rs499384) were associated with hand dermatitis. The results are of interest as they demonstrate that genetic variations in inflammation-related genes within the MHC can influence chemical-induced skin irritation and may explain the connection between inflamed skin and propensity to subsequent allergic contact sensitization.

Keywords

Health care workers; Contact dermatitis; Skin diseases; Diseases; Skin irritants; Workers; Work environment; Exposure levels; Risk factors; Genes; Irritants; Models; Dermatitis; Allergic dermatitis; Allergic reactions; Chemical properties; Sensitization; Author Keywords: Genetics; healthcare workers; irritant contact dermatitis; MHC

Contact

Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown WV, USA

CODEN

JIOMAP

Publication Date

20160901

Document Type

Journal Article

Email Address

berranyucesoy@gmail.com

Fiscal Year

2016

NTIS Accession No.

NTIS Price

ISSN

1547-691X

NIOSH Division

HELD

Source Name

Journal of Immunotoxicology

State

WV; PA; NC; OH; NV

Page 41 of 262

Page last reviewed: December 9, 2020

Content source: National Institute for Occupational Safety and Health Education and Information Division