NIOSHTIC-2 Publications Search

Search Results

New Search

Advanced Search Search Help About NIOSHTIC-2 Feedback

Terms: mead 56 - 56 of 253 Bibliographic entries

Save All Save Page View Saved Download

Select check boxes to automatically save entries, or use 'save all' or 'save page' links above.

Back to Results

Time-related increase in urinary testosterone levels and stable semen analysis parameters after bariatric surgery in men.

Authors

Legro-RS; Kunselman-AR; Meadows-JW; Kesner-JS; Krieg-EF; Rogers-AM; Cooney-RN

Source

Reprod Biomed Online 2015 Feb; 30(2):150-156

Link

http://dx.doi.org/10.1016/j.rbmo.2014.10.014

NIOSHTIC No.

20045644

Abstract

The aim of this prospective cohort study was to determine the time-course in androgen and semen parameters in men after weight loss associated with bariatric surgery. Six men aged 18-40 years, meeting National Institutes of Health bariatric surgery guidelines, were followed between 2005 and 2008. Study visits took place at baseline, then 1, 3, 6 and 12 months after surgery. All men underwent Roux-en-y gastric bypass (RYGB). At each visit, biometric, questionnaire, serum, and urinary specimens and seman analysis were collected. Urinary integrated total testosterone levels increased significantly (P < 0.0001) by 3 months after surgery, and remained elevated throughout the study. Circulating testosterone levels were also higher at 1 and 6 months after surgery, compared with baseline. Serum sex hormone-binding globulin levels were significantly elevated at all time points after surgery (P < 0.01 to P = 0.02). After RYGB surgery, no significant changes occurred in urinary oestrogen metabolites (oestrone 3-glucuronide), serum oestradiol levels, serial semen parameters or male sexual function by questionnaire. A threshold of weight loss is necessary to improve male reproductive function by reversing male hypogonadism, manifested as increased testosterone levels. Further serial semen analyses showed normal ranges for most parameters despite massive weight loss.

Keywords

Humans; Men; Age-groups; Weight-factors; Sexual-reproduction; Reproductive-effects; Author Keywords: androgens; hypogonadism; obesity; semen; sexual dysfunction; weight loss

Contact

Dr Richard S. Legro, Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA

CODEN

RBOEA6

Publication Date

20150201

Document Type

Journal Article

Email Address

rsl1@psu.edu

Fiscal Year

2015

NTIS Accession No.

NTIS Price

Issue of Publication

ISSN

1472-6483

NIOSH Division

DART

Priority Area

Manufacturing; Agriculture, Forestry and Fishing; Mining;

Source Name

Reproductive Biomedicine Online

State

PA; OH; NY

Page 56 of 253

Page last reviewed: December 9, 2020

Content source: National Institute for Occupational Safety and Health Education and Information Division