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Rapid suppression of bone formation marker in response to sleep restriction and circadian disruption in men.

Swanson CM; Kohrt WM; Wolfe P; Wright KP Jr.; Shea SA; Cain SW; Munch M; Vujovic N; Czeisler CA; Orwoll ES; Buxton OM

Osteoporos Int 2019 Dec; 30(12):2485-2493

https://doi.org/10.1007/s00198-019-05135-y

20056961

Summary: We describe the time course of bone formation marker (P1NP) decline in men exposed to approximately 3 weeks of sleep restriction with concurrent circadian disruption. P1NP declined within 10 days and remained lower with ongoing exposure. These data suggest even brief exposure to sleep and circadian disruptions may disrupt bone metabolism. Introduction: A serum bone formation marker (procollagen type 1 N-terminal, P1NP) was lower after approximately 3 weeks of sleep restriction combined with circadian disruption. We now describe the time course of decline. Methods: The approximately 3-week protocol included two segments: "baseline," >/= 10-h sleep opportunity/day x 5 days; "forced desynchrony" (FD), recurring 28 h day (circadian disruption) with sleep restriction approximately 5.6-h sleep per 24 h). Fasted plasma P1NP was measured throughout the protocol in nine men (20-59 years old). We tested the hypothesis that PINP would steadily decline across the FD intervention because the magnitude of sleep loss and circadian misalignment accrued as the protocol progressed. A piecewise linear regression model was used to estimate the slope (B) as delta P1NP per 24 h with a change point midprotocol to estimate the initial vs. prolonged effects of FD exposure. Results: Plasma P1NP levels declined significantly within the first 10 days of FD (B^ = - 1.33 ug/L per 24 h, p < 0.0001) and remained lower than baseline with prolonged exposure out to 3 weeks (B^ = - 0.18 ug/L per 24 h, p = 0.67). As previously reported, levels of a bone resorption marker (C-telopeptide (CTX)) were unchanged. Conclusion: Sleep restriction with concurrent circadian disruption induced a relatively rapid decline in P1NP (despite no change in CTX) and levels remained lower with ongoing exposure. These data suggest (1) even brief sleep restriction and circadian disruption can adversely affect bone metabolism, and (2) there is no P1NP recovery with ongoing exposure that, taken together, could lead to lower bone density over time.

Bone structure; Humans; Men; Sleep deprivation; Sleep; Exposure levels; Circadian rhythms; Metabolism; Blood plasma; Age groups; Models; TWH; Total Worker Health; Author Keywords: Bone formation; Bone loss; Circadian disruption; P1NP; Sleep restriction

C.M. Swanson, Division of Endocrinology, Metabolism and Diabetes, University of Colorado, 12801 E. 17th Ave.Mail Stop 8106, Aurora, CO 80045

OSINEP

20191201

Journal Article

Christine.Swanson@UCDenver.edu

Cooperative Agreement

2020

Cooperative-Agreement-Number-U19-OH-010154

12

0937-941X

Transportation, Warehousing and Utilities; Services

Osteoporosis International

OR; CO; MA; PA

Oregon Health & Science University, Portland, Oregon