Chart of Refrigerated/Frozen Pack Needs for Different Climates

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Outside
Temperature
Number of
Faces* Covered
with Packs
Temperature of Packs
Comment**

Greater than 75°F to 110°F (greater than 24°C to 43°C)

2***
23°F (-5°C)

Up to 48 hours
delivery with 10 hours

at 110°F (43°C)

32°F to 75°F
(0°C to 24°C)
2***
23°F (-5°C)
Up to 48 hours
delivery
4
41°F (+5°C)
Up to 24 hours
delivery

Colder than

32°F (°C)

4 to 6****
50°F (+10°C)
About 24 hours
exposure to mix of
outdoors and
heated areas
0°F (-18°C) or colder
6****
68°F (+20°C)
Prolonged, 24 to 48 hours continuous
exposure
to 0°F (-18°C)
*
Faces would include the interior surfaces of the box, including the walls, floor and lid (above the vaccines and insulating material).
**
Applies when high quality insulated boxes with walls of 1¾ inches to 2¼ inches expanded polystyrene, 1 inch isocyanurate, or 3 inches polyurethane insulation were used.
***
3 for the medium-sized box tested by CDC (10x10x7 inches—interior dimensions).
****
Essentially the entire surface area is covered with packs.

Refrigerated/Frozen Packs.

 

 
 
Centers for Disease Control and Prevention