National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention
Division of Sexually Transmitted Diseases
Program and Training Branch
Patient Management/Treatment
Patient management and treatment of VVC depends on the clinical presentation, microbiology, host factors, and response to therapy. Vulvovaginal candidiasis can be classified as uncomplicated or complicated.
Classification of Vulvovaginal Candidiasis
Uncomplicated VVC
Sporadic or infrequent vulvovaginal candidiasis Or
Mild-to-moderate vulvovaginal candidiasis Or
Likely to be C. albicans Or
Non-immunocompromised women
Complicated VVC
Recurrent vulvovaginal candidiasis (RVVC) Or
Severe vulvovaginal candidiasis Or
Non-albicans candidiasis Or
Women with uncontrolled diabetes, debilitation, or immunosuppression or those who are pregnant
Treatment for Uncomplicated VVC
The CDC-recommended treatment regimens for uncomplicated VVC include intravaginal agents and oral agents as well as over-the-counter therapeutics and prescription drugs. Uncomplicated VVC responds to all azole treatment regimens including short (3-day) and single-dose oral and vaginal therapy.
Intravaginal agents:
Butoconazole 2% cream, 5 g intravaginally for 3 days† OR
Butoconazole 2% sustained release cream, 5 g single intravaginally application OR
Clotrimazole 1% cream 5 g intravaginally for 7-14 days† OR
Clotrimazole 100 mg vaginal tablet for 7 days OR
Clotrimazole 100 mg vaginal tablet, 2 tablets for 3 days OR
Miconazole 2% cream 5 g intravaginally for 7 days† OR
Miconazole 100 mg vaginal suppository, 1 suppository for 7 days† OR
Miconazole 200 mg vaginal suppository, 1 suppository for 3 days† OR
Miconazole 1,200 mg vaginal suppository, 1 suppository for 1 days†
OR
Nystatin 100,000-unit vaginal tablet, 1 tablet for 14 days OR
Tioconazole 6.5% ointment 5 g intravaginally in a single application† OR
Terconazole 0.4% cream 5 g intravaginally for 7 days OR
Terconazole 0.8% cream 5 g intravaginally for 3 days OR
Terconazole 80 mg vaginal suppository, 1 suppository for 3 days
Oral agent:
Fluconazole 150 mg oral tablet, 1 tablet in a single dose
