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Self-Study STD Module - PID

Patient Management/Treatment (continued)

Parenteral Regimens

The CDC recommends two antimicrobial parenteral regimens: Regimen A and Regimen B.

Parenteral Regimen A
Cefotetan 2 g IV every 12 hours
OR
Cefoxitin 2 g IV every 6 hours
PLUS
Doxycycline 100 mg orally or IV every 12 hours
Parenteral Regimen B
Clindamycin 900 mg IV every 8 hours
PLUS
Gentamicin loading dose IV or IM (2 mg/kg), followed by maintenance dose (1.5 mg/kg) every 8 hours. Single daily gentamicin dosing may be substituted.

It is important to continue either Regimen A or Regimen B or alternative regimens for at least 24 hours after substantial clinical improvement occurs and also to complete a total of 14 days therapy with:

Doxycycline (100 mg orally twice a day),
OR
Clindamycin (450 mg orally four times a day)

Alternative parenteral regimens

Limited data support the use of other parenteral regimens. The following regimens have been investigated and have broad spectrum coverage and are recommended as alternative regimens by CDC.

Ampicillin/Sulbactam 3 g IV every 6 hours
PLUS
Doxycycline 100 mg orally or IV every 12 hours

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Page last modified: June 3, 2009
Page last reviewed: June 3, 2009

Content Source: Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention


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