National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention
Division of Sexually Transmitted Diseases
Program and Training Branch
Patient Management/Treatment (continued)
Parenteral Regimens
The CDC recommends two antimicrobial parenteral regimens: Regimen A and Regimen B.
Parenteral Regimen A
Cefotetan 2 g IV every 12 hours OR Cefoxitin 2 g IV every 6 hours PLUS Doxycycline 100 mg orally or IV every 12 hours
Parenteral Regimen B
Clindamycin 900 mg IV every 8 hours PLUS Gentamicin loading dose IV or IM (2 mg/kg), followed by maintenance dose (1.5 mg/kg) every 8 hours. Single daily gentamicin dosing may be substituted.
It is important to continue either Regimen A or Regimen B or
alternative regimens for at least 24 hours after
substantial clinical improvement occurs and also to complete a total of 14 days therapy
with:
Doxycycline (100 mg orally twice a day),
OR Clindamycin (450 mg orally four times a day)
Alternative parenteral regimens
Limited data support the use of other parenteral regimens. The following regimens
have been investigated and have broad spectrum coverage and are recommended as alternative
regimens by CDC.
Ampicillin/Sulbactam 3 g IV every 6 hours
PLUS Doxycycline 100 mg orally or IV every 12
hours
