- The more similar a vaccine is to the natural disease, the better the immune response to the vaccine.
- Circulating antibody has more effect on the immune response to live
attenuated vaccines than on the immune response to inactivated vaccines.
- All vaccines can be administered at the same visit as all other vaccines.
- Live attenuated vaccines generally produce long-lasting immunity with one or two doses. Inactivated vaccines generally require three or more doses and may require periodic boosting to maintain immunity.
- Increasing the interval between doses of a multidose vaccine does not diminish the effectiveness of the vaccine. Decreasing the interval between doses of a multidose vaccine may interfere
with the antibody response and protection.
- Adverse reactions following live attenuated vaccines are similar to a mild form of the natural disease. Adverse reactions following inactivated vaccines are mostly local, and may occur with
or without fever.
- There are only two permanent contraindications to vaccination:
- Severe allergic reaction to a vaccine component or following a prior dose of vaccine. (Do not give another dose of that vaccine.)
- Encephalopathy without a known cause occurring within 7 days of a dose of a pertussis-containing vaccine. (Do not give another dose of a pertussis-containing vaccine.)
- Rotavirus vaccine (both RV5 and RV1) is contraindicated in infants diagnosed with Severe Combined Immunodeficiency Disease (SCID)