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Terms: neurologic OR nervous AND system AND neurotoxi*

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An investigation of modifying effects of single nucleotide polymorphisms in metabolism-related genes on the relationship between peripheral nerve function and mercury levels in urine and hair.

Authors

Wang-Y; Goodrich-JM; Werner-R; Gillespie-B; Basu-N; Franzblau-A

Source

Sci Total Environ 2012 Feb; 417-418(2012):32-38

Link

http://dx.doi.org/10.1016/j.scitotenv.2011.12.019 

NIOSHTIC No.

20040981 

Abstract

Mercury (Hg) is a potent neurotoxicant. We hypothesized that single nucleotide polymorphisms (SNPs) in genes coding glutathione-related proteins, selenoproteins and metallothioneins may modify the relationship of mercury biomarkers with changes in peripheral nerve function. Dental professionals (n=515) were recruited in 2009 and 2010. Sensory nerve function (onset latency, peak latency and amplitude) of the median, ulnar and sural nerves was recorded. Samples of urine, hair and DNA were collected. Covariates related to demographics, nerve function and elemental and methyl-mercury exposure were also collected. Subjects included 244 dentists (47.4%) and 269 non-dentists (52.2%; mostly dental hygienists and dental assistants). The mean mercury levels in urine (1.06 µg/L) and hair (0.51 µg/g) were not significantly different from the US general population (0.95 µg/L and 0.47 µg/g, respectively). In multivariate linear models predicting nerve function adjusting for covariates, only 3 out of a total of 504 models showed stable and statistically significant interaction of SNPs with mercury biomarkers. Overall, given the possibility of false positives, the results suggested little evidence of effect modification of the SNPs on the relationship between mercury biomarkers with peripheral nerve function at exposure levels that are relevant to the general US population.

Keywords

Mercury-compounds; Biomarkers; Neurotoxins; Nucleotides; Nerve-function; Protein-biochemistry; Proteins; Genes; Genetics; Peripheral-nervous-system; Sensory-disorders; Dentistry; Dentists; Sampling; Urinalysis; DNA-damage; Methyl-compounds; Metalloproteins; Thiones; Metabolism; Mercury-poisoning; Mathematical-models; Biochemical-indicators; Physiopathology; Author Keywords: Mercury biomarker; Single nucleotide polymorphism; Nerve function; Metallothionein; Glutathione; Selenoprotein

Contact

Alfred Franzblau, M6023 SPH II, 1415 Washington Heights, University of Michigan School of Public Health, Ann Arbor, MI 48109-2029

CODEN

STENDL

CAS No.

7439-97-6; 22967-92-6; 70-18-8

Publication Date

20120215

Document Type

Journal Article

Email Address

afranz@umich.edu

Funding Type

Grant

Fiscal Year

2012

NTIS Accession No.

NTIS Price

Identifying No.

Grant-Number-T42-OH-008455; B07092012

Issue of Publication

2012

ISSN

0048-9697

Source Name

Science of the Total Environment

State

MI

Performing Organization

University of Michigan, Ann Arbor