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Terms: flavoring* or diacetyl or pentanedione or heptanedione or 2,3-hexanedione And Not heta

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Flavoring-related lung disease: information for healthcare providers.

Authors

NIOSH

Source

Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2012-148, 2012 May; :1-6

Link

http://www.cdc.gov/niosh/docs/2012-148/ 

NIOSHTIC No.

20040973 

Abstract

Severe obstructive lung disease has been identified in people who work with flavoring chemicals containing diacetyl, including butter flavoring. Animal studies suggest that some flavoring chemicals similar to diacetyl, such as 2,3-pentanedione, may also be a hazard. Cases of severe lung disease have occurred in microwave popcorn plants and flavoring production plants. Lung biopsies in some affected people have shown the presence of a rare condition; constrictive bronchiolitis obliterans (also referred to as constrictive bronchiolitis, obliterative bronchiolitis, and bronchiolitis obliterans). In some workers, fixed airways obstruction has been severe enough to be fatal.

Keywords

Lung; Lung-disease; Lung-disorders; Lung-function; Lung-irritants; Lung-tissue; Chemical-hypersensitivity; Chemical-properties; Humans; Men; Women; Exposure-limits; Exposure-levels; Workers; Respiratory-system-disorders; Pulmonary-system-disorders; Pulmonary-disorders; Fibrogenicity; Fibrosis

CAS No.

431-03-8

Publication Date

20120501

Document Type

Numbered Publication

Fiscal Year

2012

NTIS Accession No.

NTIS Price

Identifying No.

(NIOSH) 2012-148; B07092012

NIOSH Division

EID

Source Name

National Institute for Occupational Safety and Health

State

WV