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Terms: corticosterone

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Chronic exposure to corticosterone enhances the neuroinflammatory and neurotoxic responses to methamphetamine.

Authors

Kelly-KA; Miller-DB; Bowyer-JF; O'Callaghan-JP

Source

J Neurochem 2012 Sep; 122(5):995-1009

Link

http://dx.doi.org/10.1111/j.1471-4159.2012.07864.x 

NIOSHTIC No.

20041150 

Abstract

Upregulation of proinflammatory cytokines and chemokines in brain ("neuroinflammation") accompanies neurological disease and neurotoxicity. Previously, we documented a striatal neuroinflammatory response to acute administration of a neurotoxic dose of methamphetamine (METH), i.e. one associated with evidence of dopaminergic terminal damage and activation of microglia and astroglia. When we used minocycline to suppress METH-induced neuroinflammation, indices of dopaminergic neurotoxicity were not affected but suppression of neuroinflammation was incomplete.

Keywords

Brain-function; Diseases; Neurotoxicity; Neurotoxic-effects; Drugs; Corticosteroids; Neurological-diseases; Neurological-reactions; Animals; Laboratory-animals

CODEN

JONRA9

CAS No.

537-46-2

Publication Date

20120901

Document Type

Journal Article

Email Address

jdo5@cdc.gov

Fiscal Year

2012

NTIS Accession No.

NTIS Price

Identifying No.

B08012012

Issue of Publication

5

ISSN

0022-3042

NIOSH Division

HELD

Priority Area

Services: Public Safety

Source Name

Journal of Neurochemistry

State

WV; AR