NIOSHTIC-2 Search Results |
|
|
| Terms:
Relationship between cumulative effects of smoking |
1 - 1
of 11 Bibliographic entries |
|
Select check boxes to automatically save entries, or use 'save all' or 'save page' links above.
| 1 |
Relationship between cumulative effects of smoking and memory CD4+ T lymphocyte subpopulations |
| Authors |
Nakata-A; Takahashi-M; Irie-M; Fujioka-Y; Haratani-T; Araki-S |
| Source |
Addict Behav 2007 Jul; 32(7):1526-1531 |
| Link |
http://dx.doi.org/10.1016/j.addbeh.2006.11.007 |
| NIOSHTIC No. |
20032317 |
| Abstract | Previous studies have found that smoking is a strong factor that increases peripheral blood CD4+ T lymphocytes. However, most studies did not assess the cumulative long-life exposure of smoking on differential lymphocyte populations. In this study, to clarify the association of smoking habits and circulating lymphocytes, we conducted a cross-sectional study of 60 male current smokers. Smoking status was estimated by number of cigarettes smoked per day, smoking years, and Brinkman Index (BI) as calculated by multiplying the number of cigarettes smoked per day by the smoking years. Counts of CD4+CD45RO+CD69+ T and CD4+CD45RO+ T lymphocytes were strongly and positively correlated with BI and remained highly significant after controlling for alcohol drinking, leisure-time physical activity, and caffeine intake (r(p)>.465, p<.001). These lymphocytes were also significantly correlated with the number of cigarettes smoked per day and smoking years, but the association was weaker than the BI. The findings suggest that the CD4+CD45RO+CD69+ T and CD4+CD45RO+ T lymphocytes are sensitive to cumulative effect of smoking, and may serve as a potential immuno-biomarker for active smoking. | | Keywords | Exposure-levels; Time-weighted-average-exposure; Alcoholic-beverages; Physical-exercise; Blood-analysis; Immune-system; Immunological-tests; Biomarkers; Smoking; Men | | Contact | A Nakata, National Institute for Occupational Safety and Health, MS-C24, 4676 Columbia Parkway, Cincinnati, OH 45226 | | CODEN | ADBEDS | | Publication Date | 20070701 | | Document Type | Journal Article | | Email Address | nakataa-tky@umin.ac.jp | | Fiscal Year | 2007 | | NTIS Accession No. | | | NTIS Price | | | Issue of Publication | 7 | | ISSN | 0306-4603 | | NIOSH Division | DART | | Priority Area | All Sectors | | Source Name | Addictive Behaviors | | State | OH |
|