Lawson-CC; Whelan-EA; Hibert-EN; Grajewski-B; Spiegelman-D; Rich-Edwards-JW
Am J Obstet Gynecol 2009 Jan; 200(1):51.e1-51.e8
OBJECTIVE: we evaluated first-trimester exposures and the risk of preterm birth in the most recent pregnancy of participants of the Nurses' Health Study II. STUDY DESIGN: log binomial regression was used to estimate the relative risk (RR) for preterm birth in relation to occupational risk factors, such as work schedule, physical factors, and exposures to chemicals and x-rays, adjusted for age and parity. RESULTS: Part-time work (<= 20 hours a week) was associated with a lower risk of preterm birth [RR, 0.7; 95% confidence interval [CI], 0.60.9]. Working nights was associated only with early preterm birth (< 32 weeks of gestation) (RR, 3.0; 95% CI, 1.4-6.2). Although based on only 11 exposed preterm cases, self-reported exposure to sterilizing agents was associated with an increased risk (RR, 1.9; 95% CI, 1.1-3.4). CONCLUSION: these data suggest that night work may be related to early but not late preterm birth, whereas physically demanding work did not strongly predict risk.
Work-environment; Exposure-assessment; Exposure-methods; Occupational-exposure; Epidemiology; Biohazards; Biological-effects; Biological-factors; Biological-monitoring; Biological-systems; Chemical-hypersensitivity; Exposure-assessment; Exposure-levels; Exposure-limits; Exposure-methods; Statistical-analysis; Workplace-studies; Solvent-vapors; Solvents; Industrial-environment; Industrial-exposures; Industrial-factory-workers; Medical-personnel;
Author Keywords: Human exposure assessment; Deuterium-labeled DEHP; Di(2-ethylhexyl) phthalate; Occupational-exposure; Reproductive development; Oxidative metabolites; Biomarkers; Esters; Population; Health
Christina C. Lawson, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS B-20, 4676 Columbia Parkway, Cincinnati, OH 45226
Healthcare and Social Assistance
American Journal of Obstetrics and Gynecology. Presented at the 19th Annual Meeting of the Society for Pediatric and Perinatal Epidemiologic Research, Seattle, WA, June 19-20, 2006, and the 39th Annual Meeting of the Society for Epidemiologic Research, Seattle, WA, June 21-23, 2006