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Evaluation of antineoplastic drug exposure of health care workers at three university-based US cancer centers.

Authors

Connor-TH; DeBord-DG; Pretty-JR; Oliver-MS; Roth-TS; Lees-PSJ; Krieg-EF Jr; Rogers-B; Escalante-CP; Toennis-CA; Clark-JC; Johnson-BC; McDiarmid-MA

Source

J Occup Environ Med 2010 Oct; 52(10):1019-1027

Link

http://dx.doi.org/10.1097/JOM.0b013e3181f72b63 

NIOSHTIC No.

20037797 

Abstract

Objective: This study evaluated health care worker exposure to antineoplastic drugs. Methods: A cross-sectional study examined environmental samples from pharmacy and nursing areas. A 6-week diary documented tasks involving those drugs. Urine was analyzed for two specific drugs, and blood samples were analyzed by the comet assay. Results: Sixty-eight exposed and 53 nonexposed workers were studied. Exposed workers recorded 10,000 drug-handling events during the 6-week period. Sixty percent of wipe samples were positive for at least one of the five drugs measured. Cyclophosphamide was most commonly detected, followed by 5-fluorouracil. Three of the 68 urine samples were positive for one drug. No genetic damage was detected in exposed workers using the comet assay. Conclusions: Despite following recommended safe-handling practices, workplace contamination with antineoplastic drugs in pharmacy and nursing areas continues at these locations.

Keywords

Biological-factors; Biological-monitoring; Biological-systems; Biological-transport; Biomarkers; Cancer-rates; Carcinogenesis; Carcinogenicity; Carcinogens; Chemical-hypersensitivity; Drugs; Epidemiology; Exposure-assessment; Exposure-levels; Physiological-effects; Physiological-factors; Physiological-response; Reproductive-hazards; Reproductive-system-disorders; Risk-analysis; Risk-factors; Safety-measures; Statistical-analysis; Teratogenesis; Teratogens; Work-analysis; Work-areas; Work-environment; Worker-health; Work-operations; Work-performance; Workplace-studies; Work-practices

Contact

Thomas H. Connor, National Institute for Occupational Safety and Health, DART, Centers for Disease Control and Prevention, MS C-23,4676 Columbia Pkwy, Cincinnati, OH 45226

CODEN

JOEMFM

Publication Date

20101001

Document Type

Journal Article

Email Address

tmc6@cdc.gov

Fiscal Year

2011

NTIS Accession No.

NTIS Price

Issue of Publication

10

ISSN

1076-2752

NIOSH Division

DART

Source Name

Journal of Occupational and Environmental Medicine

State

OH; MD; NC; TX