Shim-YK; Silver-SR; Caporaso-NE; Marti-GE; Middleton-DC; Linet-MS; Vogt-RF
Br J Haematol 2007 Dec; 139(5):658-662
The pathogenesis of B-cell lymphoproliferative disorders in general and B-cell chronic lymphocytic leukaemia in particular appears to involve dysfunctional regulation of humoral and cellular immunity with the subsequent development of genetic aberrations in B cells. In theory, either component may arise de novo or may be influenced by environmental exposures including infectious agents, antigens, genotoxic chemicals, or radiation. As an intermediary within the exposure-disease continuum, monoclonal B-cell lymphocytosis may be a helpful biomarker for teasing out these various contributions to risk. This article introduces a series of papers that resulted from an International Workshop held in May 2007 entitled ‘Monoclonal B-cell Lymphocytosis and Chronic Lymphocytic Leukemia: Environmental and Genetic Risk Factors’. Research efforts, such as those described in this issue, should lead to improved interventions, more predictive biomarkers, more effective treatments, and a greater appreciation of how the immune system functions over the entire human lifespan.
Pathogenicity; Lymphatic-system-disorders; Lymphatic-cancer; Leukemogenesis; Leukocytes; Leukocytolysis; Risk-factors; Cell-function; Cell-metabolism; Cellular-function; Cellular-reactions; Cell-biology; Genes; Genetic-disorders; Genetic-factors; Genetics; Genotoxicity; Genotoxic-effects; Chemical-properties; Chemical-hypersensitivity; Chemical-synthesis; Antigens; Environmental-exposure; Environmental-factors; Environmental-medicine; Environmental-hazards; Environmental-contamination; Biomarkers; Biological-systems; Biological-function; Biological-factors; Biological-effects
Dr Y. K. Shim, Division of Health Studies, Agency for Toxic Substances and Disease Registry (MS: E-31), 1600 Clifton Road, NE, Atlanta, GA 30333
British Journal of Haematology