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Chronic lymphocytic leukaemia: an overview of aetiology in light of recent developments in classification and pathogenesis.

Authors

Linet-MS; Schubauer-Berigan-MK; Weisenburger-DD; Richardson-DB; Landgren-O; Blair-A; Silver-S; Field-RW; Caldwell-G; Hatch-M; Dores-GM

Source

Br J Haematol 2007 Dec; 139(5):672-686

Link

http://dx.doi.org/10.1111/j.1365-2141.2007.06847.x 

NIOSHTIC No.

20032888 

Abstract

This overview of the epidemiology of chronic lymphocytic leukaemia (CLL) summarizes the evolution of classification and coding systems and describes the intersection of pathogenesis and aetiology. The role of the putative precursor to CLL, monoclonal B-cell lymphocytosis (MBL), is considered, and ideas for future investigations of the MBL-CLL relationship are outlined. We discuss the epidemiology of CLL, focusing on descriptive patterns and methodological considerations. Postulated risk factors are reviewed including the role of ionizing and non-ionizing radiation, occupational and environmental chemical exposures, medical conditions and treatments, and lifestyle and genetic factors. We conclude by raising key questions that need to be addressed to advance our understanding of CLL aetiology. Recommendations for future epidemiological studies are given, including the standardization of reporting of CLL across cancer registries, the clarification of the natural history of MBL, and the circumvention of the methodological shortcomings of prior epidemiological investigations in relation to radiation, chemical exposures and infectious agents.

Keywords

Pathogenicity; Lymphatic-system-disorders; Lymphatic-cancer; Leukemogenesis; Epidemiology; Risk-factors; Risk-analysis; Radiation-effects; Radiation-exposure; Genes; Genetics; Cancer-rates; Chemical-properties; Chemical-hypersensitivity; Chemical-synthesis; Chemoreceptors; Radiation; Radiation-effects; Radiation-hazards; Radiation-levels; Radiation-measurement; Radiation-monitoring; Infectious-diseases

Contact

Martha S. Linet, NCI, DCEG, REB; 6120 Executive Blvd. EPS Room 7048, Bethesda, MD 20892-7238

CODEN

BJHEAL

Publication Date

20071201

Document Type

Journal Article

Email Address

linetm@mail.nih.gov

Funding Type

Grant

Fiscal Year

2008

NTIS Accession No.

NTIS Price

Identifying No.

Grant-Number-T42-OH-008491

Issue of Publication

5

ISSN

0007-1048

NIOSH Division

DSHEFS

Source Name

British Journal of Haematology

State

IA; MD; OH; NE; KY; NC

Performing Organization

University of Iowa