Background: Trends in workplace homicide rates are compared to the trends in U.S. homicides from 1993 to 2002, inclusively. The homogeneity of workplace homicide rates by victim demographics, circumstances, and types of events are also addressed. Methods: Using publicly available data from several sources, Poisson models are used to statistically compare the trends of workplace homicide rates versus U.S. homicide rates and to compare trends within categories of workplace homicides. Results: Overall, there was a significant decline in the rates of occupational homicide of approximately 6% per year during the study time period; this decline was found to be statistically greater than the decline of all U.S. homicides (5% per year). Taxi cab drivers and chauffeurs demonstrated the greatest decline of all occupational subgroups. When looking at the circumstances of workplace homicides, only the rate of homicides committed during a robbery or other crime demonstrated a significant decline. Conclusions: While workplace homicides have declined in the U.S., the declines have not occurred uniformly across demographic and occupational categories.