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Pulmonary effects of single-walled carbon nanotubes: inflammatory response, oxidative stress/signaling, and recognition by macrophages.

Authors

Kagan-VE; Rao-KMK; Kisin-ER; Young-S-H; Meighan-T; Murray-AR; Tyurina-YY; Castranova-V; Shvedova-AA

Source

Nanotechnology - Toxicological Issues and Environmental Safety (NATO Science for Peace and Security Series / NATO Science for Peace and Security Series C: Environmental Security). Simeonova PP, Opopol N, Luster MI. eds., Dordrecht, The Netherlands: Springer, 2007 May; :65-75

Link

http://dx.doi.org/10.1007/978-1-4020-6076-2_4 

NIOSHTIC No.

20032331 

Abstract

Nanosized materiaols and nano-scaled processes are believed to be beneficial for many industries as well as for medicine. However, irrational unjustified use of nanomaterials may also pose risks to human health and the environment, particularly single-walled carbon nanotubes, such as their decytotoxid effects, their ability to cause an inflammatory response, and induction of oxidative stress. Further, recognigion and engulfment of nanotubes in tissue and circulation are discussed. Possible involvement of lung fibroblast pulmonary responses to nanotubes are considered.

Keywords

Aerosols; Aerosol-particles; Airborne-particles; Airborne-fibers; Toxicology; Nanotechnology