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 1 Case-by-case assessment of adult-onset asthma attributable to occupational exposures among members of a health maintenance organization
Authors Sama-SR; Milton-DK; Hunt-PR; Houseman-EA; Henneberger-PK; Rosiello-RA 
Source J Occup Environ Med 2006 Apr; 48(4):400-407 
Link http://www.joem.org/pt/re/joem/abstract.00043764-200604000-00009.htm 
NIOSHTIC No. 20030008 
AbstractObjective: In a general population of employed persons with health insurance, what proportion of adult-onset asthma is caused by occupational exposures? Method: We conducted a 2-year prospective study to identify adult-onset asthma among health maintenance organization (HMO) members. Telephone interviews regarding occupational exposures, symptoms, medication use, and triggers were used to assess likelihood of work-related asthma for each case. Weighted estimating equations were used to adjust the proportion of asthma attributable to workplace exposures for factors associated with interview participation. Results: Overall, 29% (95% confidence interval, 25-34%) of adult-onset asthma was attributable to workplace exposures; 26% (21-30%) and 22% (18-27%) of cases had asthma attributable to occupational irritant and sensitizer exposures, respectively. Conclusions: Occupational exposures, including irritants, are important causes of adult-onset asthma. 
KeywordsOccupational-exposure; Respiratory-system-disorders; Pulmonary-system-disorders; Respiratory-irritants; Sensitization 
ContactSusan R. Sama, ScD, Harvard School of Public Health, Exposure, Epidemiology and Risk Program, 401 Park Drive, Box 15677, Landmark Center West, Room 428, Boston, MA 21286 
CODENJOEMFM 
Publication Date20060401 
Document TypeJournal Article 
Email Addressssama@hsph.harvard.edu 
Funding Amount343814 
Funding TypeGrant 
Fiscal Year2006 
NTIS Accession No. 
NTIS Price 
Identifying No.Grant-Number-K01-OH-007608 
Issue of Publication
ISSN1076-2752 
NIOSH DivisionDRDS 
Priority AreaDisease and Injury: Asthma and Chronic Obstructive Pulmonary Disease 
Source NameJournal of Occupational and Environmental Medicine 
StateMA; WV 
Performing OrganizationHarvard School of Public Health, Boston Massachusetts 
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