Racial and ethnic discrimination has been shown to occur in work organizations, yet little is known about the relationship of this stressor to occupational mental health. This paper explores the degree to which racial and ethnic groups may be subjected to discrimination at work and examines associations between discrimination and mental health indicators. In a national study, 1728 American workers were interviewed about aspects of their jobs, their exposure to racial and ethnic discrimination at work, and dimensions of their mental health. American minorities reported perceptions of discrimination at work at greater frequencies than White Americans, and findings suggested some indication of institutional discrimination against minorities. Further, White, Black, and Hispanic-Americans, who reported that they had been discriminated against, were found to have poorer mental health outcomes than their same-race counterparts, who did not acknowledge being discriminated against. These findings may be used to inform the development of occupational stress and health models that are more cross-culturally applicable.