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Surface contamination of chemotherapy drug vials and evaluation of new vial-cleaning techniques: results of three studies.

Authors

Connor-TH; Sessink-PJM; Harrison-BR; Pretty-JR; Peters-BG; Alfaro-RM; Bilos-A; Beckman-G; Bing-MR; Anderson-LM; Dechristoforo-R

Source

Am J Health Syst Pharm 2005 Mar; 62(5):475-484

Link

http://www.ajhp.org/cgi/content/full/62/5/475 

NIOSHTIC No.

20026412 

Abstract

The results of three studies that describe the external contamination of chemotherapy drug vials are presented. New techniques for the improved decontamination of vials containing cisplatin are also described. Study 1 evaluated the external contamination of drug vials with cyclophosphamide and ifosfamide in a pharmacy setting. Widespread contamination of the outside of drug vials was found with each drug. Study 2 evaluated the surface contamination of drug vials with cyclophosphamide and fluorouracil in three pharmacies. Sporadic contamination with fluorouracil was detected, while cyclophosphamide was found on most vials. In study 3, investigators compared the decontamination abilities of a standard decontamination procedure at the manufacturer level with an improved decontamination procedure and the use of sleeves to further decrease contamination. Though the methods of each study reported herein differed, the outcomes were similar. All chemotherapy drug vials studied demonstrated levels of contamination with the drug well above the limit of detection. Improved decontamination procedures, combined with the use of protective sleeves, reduced the level of platinum contamination by 90%, suggesting that standard decontamination procedures should be reconsidered. The results of these studies are consistent with several others that have reported contamination of the outside surface of drug vials for a number of chemotherapy drugs. Contamination can be reduced by using decontamination equipment and protective sleeves during the manufacturing process.

Keywords

Pharmaceuticals; Pharmaceutical-industry; Drugs; Decontamination; Protective-clothing; Protective-equipment; Antineoplastic-agents

Contact

Dr. Connor, National Institute for Occupational Safety and Health, MS C-23, 4676 Columbia Parkway, Cincinnati, OH 45226

CODEN

ASHPEK

CAS No.

50-18-0; 15663-27-1

Publication Date

20050301

Document Type

Journal Article

Email Address

tmc6@cdc.gov

Fiscal Year

2005

NTIS Accession No.

NTIS Price

Issue of Publication

5

ISSN

1079-2082

NIOSH Division

DART

Priority Area

Research Tools and Approaches: Exposure Assessment Methods

Source Name

American Journal of Health-System Pharmacy

State

OH; MO