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1	Measurement of Freon-113 exposure dose in exhaled breath samples using GC/MS with preconcentration
Authors	Viscusi-DJ; Zhuang-ZQ; Shaffer-R
Source	Abstr Pap - Am Chem Soc 228(Part 1):ANYL-083
Link	http://oasys2.confex.com/acs/228nm/techprogram/P743712.HTM
NIOSHTIC No.	20026153
Abstract	In previous work involving half-mask respirators, NIOSH found a correlation between fit factor (a quantitative measure of respirator performance) and total Freon-113 exposure dose (TFED), the amount of Freon-113 in a subject's end-exhaled breath measured 30 minutes after a simulated workplace test. Better detection methods for Freon-113 need to be developed in order to investigate the correlation for other classes of respirators. In this presentation we will describe improved strategies for measuring TFED using gas chromatography-mass spectrometry (GC-MS) with a preconcentration system. This presentation will describe column selection, detection limits, and precision of the analytical method. The effect of critical environmental parameters such as the background level of Freon-113 in the room will also be assessed. The use of GC/MS with preconcentration for exhaled breath analysis and trace detection may find suitability in other applications such as biomarker discovery, industrial hygiene and environmental monitoring.
Keywords	Sampling-methods; Sample-preparation; Sampling; Refrigerants; Analytical-methods; Analytical-processes; Respirators; Respiratory-protective-equipment; Biomarkers; Industrial-hygiene

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