CDC logoSafer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Skip navigation links Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us

Search for NIOSH Publications: NIOSHTIC-2

NIOSHTIC-2 Search Results
      Advanced Search  |  Help  |  About  |  Feedback 
Terms: 20024018 1 - 1 of 1 Bibliographic entries All record(s) shown.
Save All   |   Save Page View Saved    |    Download
Select check boxes to automatically save entries, or use 'save all' or 'save page' links above.

 1 Silicosis and end-stage renal disease
Authors Steenland-K; Rosenman-K; Socie-E; Valiante-D 
Source Scand J Work, Environ & Health 2002 Dec; 28(6):439-442 
Link http://www.sjweh.fi/show_abstract.php?abstract_id=696 
NIOSHTIC No. 20024018 
AbstractThe objective of this study was to determine the incidence of renal disease among workers with silicosis. A population of 1,328 workers with definite silicosis and adequate work history information, drawn from three states with silicosis surveillance systems, was followed. Renal disease was ascertained via linkage of the cohort with a United States register (which has existed since 1977) of end-stage renal disease. In the first analysis, it was assumed that the risk of end-stage renal disease began upon exposure to silica. In this analysis 12 cases of end-stage renal disease were found versus 15.6 expected, for a rate ratio of 0.77. Four cases of glomerular end-stage renal disease were found (standardized incidence ratio 2.65, 95% confidence interval 0.56-5.25). It is possible that some persons with end-stage renal disease died before being entered into the silicosis registers. In a second analysis, person-time at risk was assumed to begin at the date of entry into the silicosis register. A rate ratio of 1.67 (95% confidence interval 0.76-3.17) was found for end-stage renal disease on the basis of nine observed cases. The results do not clearly show that patients with silicosis have an excess of end-state renal disease, although they do suggest an excess of glomerular end-stage renal disease. Analyses were limited by small numbers and possible selection biases. 
KeywordsSilicosis; Workers; Silica-dusts; Silicates; Occupational-exposure; Exposure-levels; Risk-analysis; Risk-factors; Kidney-disorders; Kidneys; Nephrological-disorders; Nephrotoxicity; Nephrotoxins 
Page 1 of 1
All record(s) shown.