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Signaling by carcinogenic metals and metal-induced reactive oxygen species.

Authors

Harris-GK; Shi-X

Source

Mutat Res 2003 Dec; 533(1-2):183-200

Link

http://dx.doi.org/10.1016/j.mrfmmm.2003.08.025 

NIOSHTIC No.

20023933 

Abstract

Epidemiological data indicate that exposure to metal and metalloid species, including arsenic(III), chromium(VI), and nickel(II), increases the risk of cancer, particularly of the lung and skin. Alterations in normal signal transduction as a result of exposure to carcinogenic metals, and to metal-catalyzed reactive oxygen species (ROS) formation, appear to play an important role in the etiology of metal-induced carcinogenesis. Signaling components affected by metals include growth factor receptors, G-proteins, MAP kinases, and nuclear transcription factors. This article reviews current literature on the effects of carcinogenic metals and metal-induced ROS on cancer-related signaling pathways. In addition, the mechanisms by which those changes occur, and the role of those changes in carcinogenesis are discussed.

Keywords

Metals; Heavy-metals; Carcinogens; Respiratory-system-disorders; Respiratory-neoplasms; Lung-cancer; Pulmonary-system-disorders; Pulmonary-cancer; Skin-cancer; Skin-disorders

Contact

National Research Council Associate, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Rd. (M/S 2015), 26505-2888, Morgantown, WV, USA

CODEN

MUREAV

CAS No.

7440-47-3; 7440-38-2; 7440-02-0; 7440-41-7; 7440-43-9; 7440-48-4; 7439-92-1; 7440-36-0; 7439-89-6

Publication Date

20031210

Document Type

Journal Article

Fiscal Year

2004

NTIS Accession No.

NTIS Price

Issue of Publication

1-2

ISSN

0027-5107

NIOSH Division

HELD

Source Name

Mutation Research

State

WV