Authors
Stayner-L; Dankovic-D; Smith-R; Steenland-K
Source
Am J Ind Med 1998 Sep; 34(3):207-219
Abstract
Several quantitative risk assessment models have been published for occupational and environmental exposures to diesel exhaust particles (DEP). These risk assessment models are reviewed and applied to predict lung cancer for miners exposed to DEP. The toxicologically based unit risk estimates varied widely (from 2 to 220 x 10(-6) per micrograms/m3). The epidemiologically based unit risk estimates were less variable and suggest higher risks (from 100 to 920 x 10(-6) per micrograms/m3). The wide range of risk estimates derived from these analyses reflects the strong assumptions and large uncertainties underlying these models. All of the models suggest relatively high risks (i.e., > 1/1,000) for miners with long-term exposures greater than 1,000 micrograms/m3. This is not surprising, given the fact that miners may be exposed to DEP concentrations similar to those that induced lung cancer in rats and mice, and substantially higher that the exposure concentrations in the positive epidemiologic studies
Keywords
Diesel-exhausts; Diesel-emissions; Quantitative-analysis; Risk-analysis; Risk-factors; Long-term-exposure; Miners; Mining-industry;
Author Keywords: risk assessment; diesel; lung cancer
Contact
Dr. L. Stayner, National Insitute for Occupational Safety and Health, Robert Taft Laboratories C14, 4676 Columbia Parkway, Cincinnati, Ohio 45226
Document Type
Journal Article
Email Address
lts2@cdc.gov
NIOSH Division
DSHEFS; EID
Priority Area
Research Tools and Approaches; Risk Assessment Methods
Source Name
American Journal of Industrial Medicine