Over the past few decades, there has been a large increase in our understanding of the causes and mechanisms of cancer. While only 5-10% of cancers are inheritable, the majority of cancer incidences are acquired, with exposure to carcinogenic chemicals, including those found in the workplace, accounting for a significant portion of cancer-related deaths. Recent developments in cellular and molecular biology, as well as those in informatics, have enabled investigators to make significant progress in developing strategies to efficiently detect, prevent, and manage cancer. Despite the remarkable progress made, cancer continues to be a leading cause of human death worldwide. This article presents a perspective of the recent advancements in our knowledge of the process of chemical carcinogenesis.