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Nylon flock-associated interstitial lung disease.

Authors

Eschenbacher-WL; Kreiss-K; Loucheed-MD; Pransky-GS; Day-B; Castellan-RM

Source

Am J Respir Crit Care Med 1999 Jun; 159(6):2003-2008

Link

http://ajrccm.atsjournals.org/cgi/content/abstract/159/6/2003 

NIOSHTIC No.

20000847 

Abstract

A work-related interstitial lung disease has been diagnosed in workers at five nylon flock facilities in three different states and a Canadian province. The National Institute for Occupational Safety and Health hosted a workshop at which consulting pulmonary pathologists reviewed lung tissue samples from all the cases for which lung biopsy material was available(15 of 20 cases known in January 1998). After independent review and scoring of these lung tissue specimens, the pathologists reached consensus that the histopathological findings revealed a characteristic lesion-a lymphocytic bronchiolitis and peribronchiolitis with lymphoid hyperplasia represented by lymphoid aggregates. The pathologists noted that the pathological findings were distinctive when compared with known lung conditions. The clinical presentation for the cases generally included cough, dyspnea, restrictive ventilatory defect with reduction in diffusing capacity, and interstitial markings on chest radiographs or high-resolution computed tomography (HRCT) scans. Six of the cases improved after removal from workplace exposure without medical treatment. Six others, who had recovered with medical treatment and removal from the workplace, had relapses in both symptoms and objective findings after attempting to return to nylon flock work. With this and other evidence supporting the existence of chronic interstitial pneumonitis associated with nylon flock processing, workshop participants recommended surveillance for early identification of affected workers and their removal from further workplace exposure.

Keywords

Pulmonary-system-disorders; Lung-fibrosis; Lung-disorders; Fabrics; Chest-X-rays; Lung-disease; Respiratory-system-disorders

Contact

William L. Eschenbacher, M.D., DRDS/NIOSH, MS 240, 1095 Willowdale Road, Morgantown, WV 26505-2888

CODEN

AJCMED

Publication Date

19990601

Document Type

Journal Article

Email Address

wae7@cdc.gov

Fiscal Year

1999

NTIS Accession No.

NTIS Price

Issue of Publication

6

ISSN

1073-449X

NIOSH Division

DRDS

Priority Area

Asthma and Chronic Obstructive Pulmonary Disease; Pulmonary-system-disorders

Source Name

American Journal of Respiratory and Critical Care Medicine

State

WV; MA